Forkhead box (Fox) proteins are a superfamily of evolutionarily conserved transcriptional
regulators, which control a wide spectrum of biological processes. As a consequence, a loss …

Aberrant activation of β-catenin promotes cell proliferation and initiates colorectal
tumorigenesis,. However, the expansion of tumours and the inadequacy of their local …

Background Epidermal growth factor receptor (EGFR) mutations are present in the majority
of patients with non-small cell lung cancer (NSCLC) responsive to the EGFR tyrosine kinase …

Relapses and disease exacerbations are vexing features of multiple sclerosis. Osteopontin
(Opn), which is expressed in multiple sclerosis lesions, is increased in patients' plasma …

Background The epidermal growth factor receptor (EGFR) plays a critical role in the control
of cellular proliferation, differentiation, and survival. Abnormalities in EGF-EGFR signaling …

Differentiation of human endometrial stromal cells (HESCs) into decidual cells is associated
with induction of the forkhead transcription factor forkhead box O1A (FOXO1). We performed …

The molecular events involved in the establishment and maintenance of CD4+ central
memory and effector memory T cells (TCM and TEM, respectively) are poorly understood. In …

Forkhead transcription factors of the O class (FOXOs) are important targets of the
phosphatidylinositol 3-kinase (PI3-kinase)/Akt pathway. FOXOs have been implicated in the …

Aberrant activation of the phosphatidylinositol 3-kinase (PI3K)–AKT/protein kinase B-
signaling pathway has been associated with multiple human cancers, including thyroid …

It has been shown that the tumour microenvironment confers resistance to chemotherapy.
Specifically, it was previously reported that adhesion of haematopoietic tumour cells to …