MicroRNAs in human cancer: from research to therapy

M Negrini, M Ferracin, S Sabbioni… - Journal of cell …, 2007 - journals.biologists.com
Numerous miRNAs are deregulated in human cancers, and experimental evidence
indicates that they can play roles as oncogenes or tumor suppressor genes. Similarly to …

MicroRNAs and haematology: small molecules, big function

CH Lawrie - British journal of haematology, 2007 - Wiley Online Library
MicroRNAs are a recently discovered class of small (∼ 22nt) endogenously expressed
translational‐repressor RNAs that play key roles in many cellular pathways and whose …

Overexpression of micro ribonucleic acid 29, highly up-regulated in diabetic rats, leads to insulin resistance in 3T3-L1 adipocytes

A He, L Zhu, N Gupta, Y Chang… - Molecular endocrinology, 2007 - academic.oup.com
Micro-RNAs (miRNAs) have been suggested to play pivotal roles in multifarious diseases
associated with the posttranscriptional regulation of protein-coding genes. In this study, we …

CD34+ hematopoietic stem-progenitor cell microRNA expression and function: a circuit diagram of differentiation control

RW Georgantas III, R Hildreth… - Proceedings of the …, 2007 - National Acad Sciences
MicroRNAs (miRNAs) are a recently identified class of epigenetic elements consisting of
small noncoding RNAs that bind to the 3′ untranslated region of mRNAs and down …

miRNA expression profiles in chronic lymphocytic and acute lymphocytic leukemia

DL Zanette, F Rivadavia, GA Molfetta… - Brazilian Journal of …, 2007 - SciELO Brasil
MicroRNAs (miRNAs) are a class of small endogenous RNAs that play important regulatory
roles by targeting mRNAs for cleavage or translational repression. miRNAs act in diverse …

MicroRNA miR-181a correlates with morphological sub-class of acute myeloid leukaemia and the expression of its target genes in global genome-wide analysis

S Debernardi, S Skoulakis, G Molloy, T Chaplin… - Leukemia, 2007 - nature.com
MicroRNAs (miRNAs) are short single-stranded RNAs that have a potentially important role
in gene regulation. Using a quantitative real-time polymerase chain reaction assay specific …

[HTML][HTML] Regulated expression of microRNAs in normal and polycythemia vera erythropoiesis

H Bruchova, D Yoon, AM Agarwal, J Mendell… - Experimental …, 2007 - Elsevier
OBJECTIVE: Polycythemia vera (PV) is a myeloproliferative disorder, arising from the
acquired mutation (s) of a hematopoietic stem cell. The JAK2 V617F somatic mutation is …

Expression patterns of microRNAs 155 and 451 during normal human erythropoiesis

S Masaki, R Ohtsuka, Y Abe, K Muta… - … and biophysical research …, 2007 - Elsevier
To clarify the roles of microRNAs (miRNAs) in erythropoiesis, the expression of miR-155,
miR-221, miR-223, and miR-451 were analyzed during the differentiation of purified normal …

Regulation of pri-microRNA BIC transcription and processing in Burkitt lymphoma

J Kluiver, A van den Berg, D de Jong, T Blokzijl… - Oncogene, 2007 - nature.com
BIC is a primary microRNA (pri-miR-155) that can be processed to mature miR-155. In this
study, we show the crucial involvement of protein kinase C (PKC) and nuclear factor-κB (NF …

A simple array platform for microRNA analysis and its application in mouse tissues

X Tang, J Gal, X Zhuang, W Wang, H Zhu, G Tang - Rna, 2007 - rnajournal.cshlp.org
MicroRNAs (miRNAs) are a novel class of small noncoding RNAs that regulate gene
expression at the post-transcriptional level and play a critical role in many important …