Treatment‐related acute myeloid leukaemia (t‐AML) is a devastating complication following
exposure to the cytotoxic and genotoxic agents used to treat a primary malignancy. Whilst …

Background Polymorphisms in DNA repair genes have been associated to repair DNA
lesions, and might contribute to the individual susceptibility to develop different types of …

We investigated association between polymorphisms in DNA repair genes and the capacity
to repair DNA damage induced by γ-irradiation and by base oxidation in a healthy …

Base excision repair can be measured in human lymphocytes by a variety of techniques, the
most convenient of which are probably in vitro assays of the activity of a cell extract on a …

To assess whether DNA repair gene variants influence the clinical behaviour of lung cancer
we examined the impact of a comprehensive panel of 109 non-synonymous single …

DNA repair gene alterations have been shown to cause a reduction in DNA repair capacity.
We hypothesised that DNA repair gene polymorphisms may be risk factors for prostate …

Susceptibility to cancer has been associated with DNA repair capacity, a global reflection of
all functional variants, most of which are relatively rare. Among the 1,098 single nucleotide …

Coronary artery disease (CAD) is a multifactorial process that appears to be caused by the
interaction of environmental risk factors with multiple predisposing genes. In this study, we …

Repair of damage to DNA resulting from chemotherapy may influence drug toxicity and
survival in response to treatment. We evaluated the role of polymorphisms in DNA repair …

We evaluated the association between the XPD exon 10 Asp312Asn and exon 23
Lys751Gln polymorphisms and the risk of pancreatic cancer in a hospital-based study of 344 …