Fatty acids are essential compounds in the cell. Since the yeast Saccharomyces cerevisiae
does not feed typically on fatty acids, cellular function and growth relies on endogenous …

In eukaryotic cells, PA2 is a central precursor for the synthesis of major
glycerophospholipids, DAG and TAG, as well as a major signaling lipid. In mammalian cells …

The last several years have been witness to significant developments in understanding
transcriptional regulation of the yeast phospholipid structural genes. The response of most …

The emerging field of lipidomics, driven by technological advances in lipid analysis,
provides greatly enhanced opportunities to characterize, on a quantitative or semi …

In the present study, we have used DNA microarray and quantitative real-time PCR analysis
to examine the transcriptional changes that occur in response to cellular depletion of the …

Snf1, the yeast AMP kinase homolog, is essential for derepression of glucose-repressed
genes that are activated by Adr1. Although required for Adr1 DNA binding, the precise role …

Abstract The 2001 Nobel Prize in Medicine, awarded to two yeast researchers for
contributions to understanding the eukaryotic cell cycle, spotlighted yeast as an …

Most of the phospholipid biosynthetic genes of yeast are regulated at the transcriptional
level in response to inositol and choline. Inositol-mediated regulation requires a promoter …