Autoimmune diabetes occurs when invading lymphocytes destroy insulin-producing β cells
in pancreatic islets. The role of lymphocytic aggregates at this inflammatory site is not …

Autoimmune diabetes is believed to be mediated primarily by T cells. However, B cells have
been implicated in the pathogenesis of the disease in NOD mice. Although preclinical …

The NOD mouse is an invaluable model for the study of autoimmune diabetes. Furthermore,
although less appreciated, NOD mice are susceptible to other autoimmune diseases that …

The H2 g7 (Kd, Ag7, Enull, and Db) major histocompatibility complex (MHC) is the primary
genetic contributor to type 1 diabetes in NOD mice. NOD stocks congenically expressing …

Introduction 3. An important role for B cells in T1D 4. What is the role of B cells in T1D? 4.1. B
cells function as a diabetogenic APC 4.2. Specific Ig-mediated antigen capture allows B …

The immune system contains three different branches: innate immunity, adaptive immunity
and innate-like lymphocytes that share properties both with the innate and adaptive immune …

Дисертація містить дані про величину відносних площ і щільності імунокомпетентних
клітин структурних компонентів білої пульпи селезінки: лімфоїдних вузликів та їх …

Systemic lupus erythematosus (SLE) is a devastating systemic autoimmune disease marked
by the production of antinuclear autoantibodies whose etiology has both genetic and …

In Type 1 diabetes, beta-cells is subjected to an autoimmune-mediated apoptotic and
inflammatory attack. Whilst lymphocytes are the primary contributor of beta-cell death …

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the
production of anti-nuclear autoantibodies to Smith (Sm), a component of a ribonucleoprotein …