Over the years, p53 has been shown to sit at the centre of an increasingly complex web of
incoming stress signals and outgoing effector pathways. The number and diversity of stress …

p53 mutations are found in 50% of human cancers. Molecular epidemiology has shown
strong correlations between the spectrum of p53 mutations and exposure to exogenous …

The S100 proteins are exclusively expressed in vertebrates and are the largest subgroup
within the superfamily of EF-hand Ca 2+-binding proteins Generally, S100 proteins are …

Hepcidin is an iron‐regulatory protein that is upregulated in response to increased iron or
inflammatory stimuli. Hepcidin reduces serum iron and induces iron sequestration in the …

For pediatric cancers like neuroblastoma, the most common extracranial solid tumor of
infancy, p53 mutations are rare at diagnosis, but may be acquired after chemotherapy …

The tumor suppressor protein p53 is a transcription factor that is frequently mutated in
human cancers. In response to DNA damage, unmutated or wild-type (wt) p53 protein is …

The efficacy of Onconase on the growth of a panel of chemosensitive and chemoresistant
neuroblastoma cell lines was investigated. Onconase decreased cell viability of …

p53 is a key modulator of a variety of cellular stresses. In human neuroblastomas, p53 is
rarely mutated and aberrantly expressed in cytoplasm. In this study, we have identified a …

Neuroblastoma (NB) is the most common solid malignancy in childhood and its prognosis is
still generally poor. In contrast to many other cancers, mutations of the p53 tumor suppressor …

Aberrant cytoplasmic sequestration has been reported as an alternative mechanism of p53
inactivation to mutation in neuroblastoma. We hypothesized that p53 localization and …