Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome

FS Sutterwala, LA Mijares, L Li, Y Ogura… - The Journal of …, 2007 - rupress.org
Pseudomonas aeruginosa is a Gram-negative bacterium that causes opportunistic infections
in immunocompromised individuals. P. aeruginosa employs a type III secretion system to …

Further characterization of a type III secretion system (T3SS) and of a new effector protein from a clinical isolate of Aeromonas hydrophila—part I

J Sha, SF Wang, G Suarez, JC Sierra, AA Fadl… - Microbial …, 2007 - Elsevier
A type III secretion system (T3SS)-associated cytotoxin, AexT, with ADP-ribosyltransferase
activity and homology to Pseudomonas aeruginosa bifuncational toxins ExoT/S, was …

Life at the front: dissecting bacterial-host interactions at the ocular surface

DJ Evans, NA McNamara, SMJ Fleiszig - The ocular surface, 2007 - Elsevier
The ocular surface usually looks quiet, presenting a general impression of biological
inactivity. Yet, the ability of the cornea to maintain health while continually exposed to …

The ubiquitin ligase Cbl-b limits Pseudomonas aeruginosa exotoxin T–mediated virulence

P Balachandran, L Dragone… - The Journal of …, 2007 - Am Soc Clin Investig
Pseudomonas aeruginosa, an important cause of opportunistic infections in humans,
delivers bacterial cytotoxins by type III secretion directly into the host cell cytoplasm …

Melittin as an epithelial permeability enhancer I: investigation of its mechanism of action in Caco-2 monolayers

S Maher, L Feighery, DJ Brayden, S McClean - Pharmaceutical research, 2007 - Springer
Purpose Melittin is an amphipathic antimicrobial peptide which has been shown to enhance
the permeability of mannitol and reduce transepithelial electrical resistance (TER) across …

Pseudomonas aeruginosa and sPLA2 IB stimulate ABCA1-mediated phospholipid efflux via ERK-activation of PPARα–RXR

M Agassandian, OL Miakotina, M Andrews… - Biochemical …, 2007 - portlandpress.com
Bacterial infection triggers an acute inflammatory response that might alter phospholipid
metabolism. We have investigated the acute-phase response of murine lung epithelia to …

Mutation of the phospholipase catalytic domain of the Pseudomonas aeruginosa cytotoxin ExoU abolishes colonization promoting activity and reduces corneal …

C Tam, SE Lewis, WY Li, E Lee, DJ Evans… - Experimental eye …, 2007 - Elsevier
We have previously shown that ExoU, a type III secreted cytotoxin of Pseudomonas
aeruginosa, causes acute cytotoxicity towards corneal epithelial cells in vitro, and …

Use of a novel coinfection system reveals a role for Rac1, H-Ras, and CrkII phosphorylation in Helicobacter pylori-induced host cell actin cytoskeletal rearrangements

S Brandt, S Shafikhani, P Balachandran… - FEMS Immunology & …, 2007 - academic.oup.com
Abstract The Helicobacter pylori CagA protein induces profound morphological changes in
the host cytoskeleton and cell scattering, but the signalling involved is poorly understood …

Pseudomonas aeruginosa internalization by non-phagocytic cells

J Engel - Pseudomonas: A Model System in Biology, 2007 - Springer
Pseudomonas aeruginosa is one of the most virulent opportunistic infectious agents of man.
Despite constant exposure to this bacterium, ubiquitously found in water, plants, and soil …

Type III Secretory Proteins in Pseudomonas aeruginosa

H Sato, DW Frank - Virulence Mechanisms of Bacterial …, 2007 - Wiley Online Library
Pseudomonas aeruginosa is a normal inhabitant of soil and water and is ubiquitous in the
environment. Importantly, P. aeruginosa uses additional bacterial products encoded by the …