Beside the well-known deficiency in serotonergic neurotransmission as pathophysiological
correlate of major depression (MD), recent evidence points to a pivotal role of increased …

ContextExcessive calorie intake and subsequent obesity increases the risk of developing
chronic disease and decreases life expectancy. In rodent models, calorie restriction with …

Biological markers for depression are of great interest to aid in elucidating the causes of
major depression. We assess currently available biological markers to query their validity for …

Abstract Dehydroepiandrosterone (DHEA)[prasterone] is typically secreted by the adrenal
glands and its secretory rate changes throughout the human lifespan. When human …

In a vicious cycle, poor nutritional health leads to acute and chronic disease, and disease
states are catastrophic to nutritional health. The magnitude of nutritional depletion from any …

In animals and in humans, infectious diseases pose one of the most serious challenges for
survival and reproduction. This challenge constitutes a major selective force for the evolution …

Anticachexic or antisarcopenic medications are prescribed worldwide for geriatric patients
with poor appetite and associated weight loss. They represent a valuable treatment option …

Heat shock proteins (Hsp) are ubiquitously expressed proteins, which are highly inducible
by a variety of stressful stimuli. As organisms age, various denatured proteins such as …

Neben dem Monoaminmangelkonzept als pathophysiologischem Korrelat der depressiven
Störung wird zunehmend die Rolle der gesteigerten glutamatergen Neurotransmission …

Background: Information is scarce about the inflammatory responses to infection in elderly
patients. Objective: To investigate the inflammatory pattern in elderly patients with systemic …