Nuclear factor (NF)-κB and inhibitor of NF-κB kinase (IKK) proteins regulate many
physiological processes, including the innate-and adaptive-immune responses, cell death …

Ubiquitination is a reversible posttranslational modification of cellular proteins, in which a 76–
amino acid polypeptide, ubiquitin, is primarily attached to the ϵ-amino group of lysines in …

Inhibitor of apoptosis (IAP) proteins are antiapoptotic regulators that block cell death in
response to diverse stimuli. They are expressed at elevated levels in human malignancies …

Transforming growth factor β activated kinase-1 (TAK1), a member of the mitogen-activated
protein kinase kinase kinase family, has emerged as a key regulator of signal transduction …

Inflammation has evolved as a protective response to insult or injury, it's a primordial
response that eliminates or neutralises foreign organisms or material, the resolution of …

Binding of inflammatory cytokines to their receptors, stimulation of pathogen recognition
receptors by pathogen-associated molecular patterns, and DNA damage induce specific …

The TNF-related apoptosis-inducing ligand, TRAIL, has been shown to selectively kill
tumour cells. This property has made TRAIL and agonistic antibodies against its death …

Zinc-fingers (ZnFs) are extremely abundant in higher eukaryotes. Once considered to
function exclusively as sequence-specific DNA-binding motifs, ZnFs are now known to have …

Ubiquitin (Ub) and interferon-stimulated gene product 15 (ISG15) reversibly conjugate to
proteins and mediate important innate antiviral responses. The ovarian tumor (OTU) domain …

Covalent attachment of ubiquitin-like proteins (Ubls) is a predominant mechanism for
regulating protein function in eukaryotes. Several structurally related Ubls, such as ubiquitin …