The development of organisms requires concerted changes in gene activity. The free radical
theory of development proposes that oxygen serves as a morphogen to educe development …

HIV‐1 gene expression is the major determinant regulating the rate of virus replication and,
consequently, AIDS progression. Following primary infection, most infected cells produce …

Butyrate is a histone deacetylase inhibitor (HDACi) with anti-neoplastic properties, which
theoretically reactivates epigenetically silenced genes by increasing global histone …

Transcriptional activation of the major histocompatibility complex (MHC) by IFNγ is a key
step in cell-mediated immunity. At an early stage of IFNγ induction, chromatin carrying the …

We have compared the distribution of endogenous heterochromatin protein 1 (HP1) proteins
(α, β and γ) in different epithelial lines, pluripotent stem cells and embryonic fibroblasts. In …

The epigenetic status of a donor nucleus has an important effect on the developmental
potential of embryos produced by somatic cell nuclear transfer (SCNT). In this study, we …

Pre‐lamin A undergoes subsequent steps of post‐translational modification at its C‐
terminus, including farnesylation, methylation, and cleavage by ZMPSTE24 metalloprotease …

Dysregulation of connexin expression is believed to have a role in carcinogenesis, because
levels of connexin are reduced in various tumors. We examined the role of connexin 43 …

Image cytometric study of pathological specimens or cell lines has suggested that epigenetic
mechanisms are likely to play a major role in determining chromatin patterns evaluable …

Mammalian heterochromatin protein 1 (HP1α, HP1β, HP1γ subtypes) and transcriptional
intermediary factor TIF1β play an important role in the regulation of chromatin structure and …