Carbapenemases are β-lactamases with versatile hydrolytic capacities. They have the ability
to hydrolyze penicillins, cephalosporins, monobactams, and carbapenems. Bacteria …

Carbapenems, such as imipenem and meropenem, are most often used to treat infections
caused by enterobacteria that produce extended-spectrum β-lactamases, and the …

The Klebsiella pneumoniae carbapenem (KPC) β-lactamase occurs in Enterobacteriaceae
and can confer resistance to all β-lactam agents including carbapenems. The enzyme may …

Carbapenemases are β-lactamases that hydrolyze most β-lactams including carbapenems.
Carbapenemases are classified in four molecular classes; those belonging to class A are …

ABSTRACT A carbapenem-resistant isolate of Klebsiella pneumoniae producing class A
carbapenemase KPC-2 was identified in Zhejiang, China. The KPC-2 gene was located on …

Carbapenem resistance due to KPC has rarely been observed outside the United States.
We noticed a sharp increase in carbapenem-resistant Klebsiella pneumoniae strains …

Background Carbapenems are frequently used to treat infections due to extended-spectrum
β-lactamase-producing Klebsiella pneumoniae. Thus, the emergence of infections due to …

Klebsiella pneumoniae (Kp) is an important pathogen both in the community and the
hospital setting. In the community the emergence of virulent organisms with predominantly …

β-Lactamases inactivate β-lactam antibiotics and are a major cause of antibiotic resistance.
The recent outbreaks of Klebsiella pneumoniae carbapenem resistant (KPC) infections …

This report describes an outbreak of carbapenem-resistant KPC-3-producing Klebsiella
pneumoniae outside the USA. Ninety patients from different departments of a tertiary …