Chemokines are critical mediators of cell migration during routine immune surveillance,
inflammation, and development. Chemokines bind to G protein–coupled receptors and …

The belief that G protein-coupled receptors exist and function as monomeric, non-interacting
species has been largely supplanted in recent years by evidence, derived from a range of …

Approaches to identify G protein-coupled receptor oligomers rather than dimers have been
lacking. Using concatamers of fluorescent proteins, we established conditions to monitor …

The chemokine RANTES (regulated upon activation, normal T-cell expressed and secreted)
is a natural ligand of CCR5, one of the major HIV-1 coreceptors. It is secreted as part of the …

Oligomerization of the Class II G protein-coupled secretin receptor has been reported, but
the molecular basis for this and its functional significance have not been determined. In the …

Studies on olfactory receptor (OR) pharmacology have been hindered by the poor plasma
membrane localization of most ORs in heterologous cells. We previously reported that …

A full picture of the similarities between Family A and Family B GPCRs (G-protein coupled
receptors) has been frustrated by the lack of clear homology between the respective …

In G protein-coupled receptors (GPCRs), the interaction between the cytosolic ends of
transmembrane helix 3 (TM3) and TM6 was shown to play an important role in the transition …

Exposure to human immunodeficiency virus (HIV)-1 does not inevitably result in infection
and resistance to HIV-1 infection is observed in different categories of at-risk individuals. In …

To date, all mammalian chemokine receptors and chemokine-binding proteins belong to the
seven-transmembrane (7TM)-spanning family of receptors, which are typically, although not …