Chronic obstructive pulmonary disease (COPD) is an increasing health problem and one of
the leading causes of morbidity and mortality worldwide, but knowledge about its …

Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease that is
characterized by progressive airway obstruction that, unlike asthma, is relatively insensitive …

The aim of this pilot study was to explore the relative efficacy in terms of improvement in
symptoms and lung function of combining fluticasone propionate/salmeterol combination …

We conducted a double blind, randomised, placebo-controlled, crossover study evaluating
the effects of halving inhaled steroid dosage plus salmeterol, or salmeterol and tiotropium …

Background Clinical trials of tiotropium have principally recruited patients from secondary
care with more severe chronic obstructive pulmonary disease (COPD), and typically had …

Tiotropium is a potent, long-acting, selective anticholinergic bronchodilator. Treatment with
tiotropium produces sustained improvements in lung function, particularly FEV1 (peak …

We explored the additive effect of titrated oral theophylline in patients with stable chronic
obstructive pulmonary disease (COPD) who received both tiotropium, 18μg od, and …

Because additive effects of inhaled corticosteroids and long-acting anticholinergics are
unclear, we undertook this study to compare the efficacy of tiotropium alone and tiotropium …

Premature discontinuation from clinical trials may bias results against effective therapies. In
the present study mortality rates were retrospectively reviewed in a 6-month, randomised …

Patients with COPD are frequently prescribed inhaled corticosteroids (ICS); however, it is
unclear whether the treatment with ICS might modify responses to inhaled bronchodilators …