Mutations in the MYH9 gene encoding the nonmuscle myosin heavy chain IIA result in
bleeding disorders characterized by a macrothrombocytopenia. To understand the role of …

The gene implicated in the May-Hegglin anomaly and related macrothrombocytopenias,
MYH9, encodes myosin-IIA, a protein that enables morphogenesis in diverse cell types …

Megakaryocytes are highly specialized precursor cells that function solely to produce and
release platelets into the circulation. Understanding mechanisms by which megakaryocytes …

This review on platelet research focuses on defects of adhesion, cytoskeletal organisation,
signal transduction and secretion. Platelet defects can be studied by different laboratory …

Objective: MYH9 disorders are characterised by giant platelets, thrombocytopenia, and
Döhle body‐like cytoplasmic granulocyte inclusion bodies that result from mutations in …

Inherited macrothrombocytopenia is a rare illness that is often misdiagnosed as idiopathic
thrombocytopenia (ITP), a more widespread acquired disease. Automated blood cell …

Objective: Hereditary thrombocytopenias characterized by mutations in the gene for non‐
muscle myosin heavy chain IIA (NMMHC‐IIA) are known as MYH9‐related hereditary …

Platelet function defects are caused by rare congenital or, more frequently, by acquired
disorders. They may lead to bleeding or thrombotic tendencies despite of normal platelet …

The role of the anti‐cancer agent Viscum album agglutinin‐I (VAA‐I) in leukaemia PLB‐985
cells differentiated toward a neutrophil‐like phenotype by dimethylsulphoxide (PLB‐985D) …

We investigated whether or not human disease-causing, amino acid substitutions in MYH9
could cause dominant phenotypes when introduced into the sole non-muscle myosin II …