Here, we discuss the identity, heterogeneity and functions of radial glial cells mostly in the
developing central nervous system (CNS). First, we define radial glial cells by …

The mammalian central nervous system is organized by a variety of cells such as neurons
and glial cells. These cells are generated from a common progenitor, the neural stem cell …

Recently increasing reported data have suggested that only a small subset of cancer cells
possess capability to initiate malignancies including leukemia and solid tumors, which was …

Understanding normal and cancer stem cells may provide insight into the origin of and new
therapeutics for prostate cancer. Normal and cancer stem cells in prostate have recently …

Expansion of the neocortex requires symmetric divisions of neuroepithelial cells, the primary
progenitor cells of the developing mammalian central nervous system. Symmetrically …

Human brain tumor stem cells have been enriched using antibodies against the surface
protein CD133. An antibody recognizing CD133 also served to isolate normal neural stem …

Although flow cytometry is useful for studying neural lineage relationships, the method of
dissociation can potentially bias cell analysis. We compared dissociation methods on …

Objective: In recent years, a growing body of evidence has been reported that a tumor clone
is organized as a hierarchy that originates from rare stem cells. CD133, a cell surface …

The apical domain of epithelial cells is composed of distinct subdomains such as microvilli,
primary cilia and a non-protruding region. Using the cholesterol-binding protein prominin-1 …

The extracellular matrix (ECM) provides both a physical framework and a microenvironment
that supplies instructive signals from the earliest stages of multicellular development. As a …