Rationale Nucleus accumbens glutamate transmission has been implicated in drug-seeking
behavior, but the involvement of glutamate receptor subtypes in drug seeking maintained by …

BACKGROUND: Aripiprazole (Abilify) is an atypical antipsychotic drug primarily
characterized by partial agonist activity at dopamine (DA) D2 receptors and low side effects …

Cocaine-associated cues acquire incentive motivational effects that manifest as craving in
humans and cocaine-seeking behavior in rats. We have reported an increase in neuronal …

The learning processes underlying the formation of drug–cue associations involve changes
in synaptic transmission mediated by AMPA receptors. Here, we examine the consequences …

A critical event in the development of behavioral sensitization is a transient increase in
excitatory drive to dopamine neurons of the ventral tegmental area (VTA). This is likely to be …

Nucleus accumbens glutamate transmission plays a critical role in cocaine priming-induced
reinstatement of drug seeking. Previous studies have demonstrated that systemic or intra …

Rationale Acamprosate (calcium acetylhomotaurinate) is a glutamatergic neuromodulator
used for the treatment of alcoholism, but its potential efficacy in the treatment of …

Publisher Summary Brain science is at the core of future understanding of how drugs affect
behavior and their consequent impact the society. Extraordinary advances in the past three …

The efficacy of 1-methyl-1, 2, 3, 4-tetrahydroisoquinoline (1MeTIQ), a member of
endogenous tetrahydroisoquinolines, in cocaine-and food-maintained responding in self …

The ability of cues specifically unpaired with amphetamine to inhibit the expression of
sensitization was assessed. Rats in one group (Paired) received amphetamine injections in …