Notch signaling is one of key pathways constituting the stem cell signaling network. DLL1,
DLL3, DLL4, JAG1 and JAG2 with DSL domain are typical Notch ligands, while DNER …

Abstract The cytoplasmic tail of Notch ligands drives endocytosis, mediates association with
proteins implicated in the organization of cell-cell junctions and, through regulated intra …

Background The Notch signaling pathway is an evolutionarily conserved intercellular
signaling module essential for cell fate specification that requires endocytosis of Notch …

The molecular mechanisms of endothelial differentiation into a functional vascular network
are incompletely understood. To identify novel factors in endothelial development, we used …

Neuronal communication requires the coordinated assembly of polarized structures
including axons, dendrites, and synapses. Here, we report the identification of a ubiquitin …

Limited information is available about the roles of RING-finger proteins in plant defense. A
pepper CaRFP1 encoding the C3-H-C4 type RING-finger protein that physically interacted …

Both mind bomb (mib) and mind bomb-2 (mib2) encode RING E3 ubiquitin ligases that
promote Delta ubiquitylation and endocytosis in Notch activation. Detailed morphological …

It was already known that both mind bomb (mib) and mind bomb-2 (mib2) encode E3
ubiquitin ligases that target Delta in Notch activation. Here we further demonstrated that …

Mib1 and Mib2 ubiquitin ligases are very similar in their domain construction. They partake
in the Notch signaling pathway by ubiquitinating the Notch receptors Delta and Jagged prior …

The molecular mechanisms of endothelial differentiation into a functional vascular network
are incompletely understood. To identify novel factors in endothelial development we …