Cystic fibrosis (CF) lung disease reflects the failure of airways defense against chronic
bacterial infection. Studies of CF cultures, transgenic mice, and CF patients suggest that the …

Cystic fibrosis (CF) lung disease reflects persistent bacterial infection of airway lumens.
Several hypotheses have been advanced to link mutations in the CFTR gene to the failure of …

Cystic fibrosis (CF) lung disease involves chronic bacterial infection of retained airway
secretions (mucus). Recent data suggest that CF lung disease pathogenesis reflects the …

Exposed to a diverse array of potentially noxious agents, the respiratory tract is protected by
a highly developed innate defense system. Physiologically regulated epithelial ion and …

The epithelial sodium channel (ENaC) represents the rate-limiting step of sodium absorption
across airway epithelia and thereby constitutes the major pathway for volume absorption …

The efficiency of the mucociliary clearance (MCC) process that removes noxious materials
from airway surfaces depends on the balance between mucin secretion, airway surface …

In the lungs, the first line of defence against bacterial infection is the thin layer of airway
surface liquid (ASL) lining the airway surface. The superficial airway epithelium exhibits …

One of the major challenges facing the pharmaceutical field is the identification of
novel,'druggable'targets common to distinct diseases that, despite their clinical diversity …

Cystic fibrosis patients exhibit lung disease consistent with a failure of innate airway defense
mechanisms. The link between abnormal ion transport and disease initiation and …

Epithelial cells are exposed to a variety of mechanical forces, but little is known about the
impact of these forces on epithelial ion channels. Here we show that mechanical activation …