Antigen presentation by professional antigen‐presenting cells (pAPCs) to cytotoxic CD8+ T
cells can occur via two processing routes–the direct and cross‐presentation pathways …

Covalent conjugation of Toll-like receptor ligands (TLR-L) to synthetic antigenic peptides
strongly improves antigen presentation in vitro and T lymphocyte priming in vivo. These …

This study describes a method for increasing the immunogenicity of influenza virus vaccines
by exploiting the natural anti-Gal antibody to effectively target vaccines to antigen-presenting …

Although inhibitory Fcγ receptors have been demonstrated to promote mucosal tolerance,
the role of activating Fcγ receptors in modulating T helper type (Th) 2-dependent …

Chimeric human papillomavirus virus-like particles (HPV cVLP) are immunogens able to
elicit potent CTL responses in mice against HPV16-transformed tumors; however, the …

Dendritic cells (DCs) are important antigen-presenting cells (APCs) that can prime naive T
cells and control adaptive immune responses with respect to magnitude, memory and self …

Background Unlike most acute viral infections controlled with the appearance of virus-
specific neutralizing antibodies (NAbs), primary HIV infections are not met with such potent …

Dendritic cells (DCs) are capable of initiating adaptive immune responses against infectious
agents by presenting pathogen-derived antigens on MHC molecules to naïve T cells …

Dendritic cells (DCs) can be activated by signaling via pathogen receptors, by interaction
with activated T cells or by exposure to inflammatory mediators. Clearance of apoptotic cells …

A large proportion of human cancers show deficiencies in the MHC class I antigen-
processing machinery. Such defects render tumors resistant to immune eradication by …