The distinct protein aggregates that are found in Alzheimer's, Parkinson's, Huntington's and
prion diseases seem to cause these disorders. Small intermediates—soluble oligomers—in …

The histological hallmark of Parkinson's disease (PD) is the presence of fibrillar aggregates
called Lewy bodies (LBs). LB formation has been considered to be a marker for neuronal …

Aggregation of α‐synuclein, an abundant and conserved pre‐synaptic brain protein, is
implicated as a critical factor in several neurodegenerative diseases. These diseases …

For more than a decade, researchers have refined criteria for the diagnosis of dementia with
Lewy bodies (DLB) and at the same time have recognized that cognitive impairment and …

Degeneration of dopaminergic neurons in the substantia nigra is characteristic for
Parkinson's disease (PD), the second most common neurodegenerative disorder …

Mutations in the synaptic protein α-synuclein cause rare genetic forms of Parkinson's
disease. α-Synuclein is thought to play a critical role in more common sporadic cases of …

Objective Health or disease is shaped for all individuals by interactions between their genes
and environment. Exactly how the environment changes gene expression and how this can …

Leucine-rich repeat kinase 2 (LRRK2), a product of a causative gene for the autosomal-
dominant form of familial Parkinson's disease (PARK8), harbors a Ras-like small GTP …

Parkinson's disease (PD) and dementia with Lewy bodies (DLB) are both characterized
pathologically by the presence of neuronal inclusions termed Lewy bodies (LBs). A common …

Synuclein was initially named for its localization in both presynaptic nerve terminals and
portions of nuclear envelope. However, subsequent studies only confirmed the presynaptic …