Few organisms are able to withstand desiccation stress; however, desiccation tolerance is
widespread among plant seeds. Survival without water relies on an array of mechanisms …

Fibronectin (FN) is secreted as a disulfide-bonded FN dimer. Each subunit contains three
types of repeating modules: FN-I, FN-II, and FN-III. The interactions of α5β1 or αv integrins …

Recent investigations have shown that D-aspartate (D-Asp) plays an important physiological
role (s) in the mammalian body. Here, several recent studies of free D-Asp metabolism in …

The discovery of prion disease transmission in mammals, as well as a non-Mendelian type
of inheritance in yeast, has led to the establishment of a new concept in biology, the prion …

The aspartic acid residues (Asp) present in the complementarity-determining regions
(CDRs) of the light chains of two recombinant monoclonal antibodies (MAbs), MAb I and …

The pro-survival protein Bcl-xL is critical for the resistance of tumour cells to DNA damage.
We have previously demonstrated, using a mouse cancer model, that oncogenic tyrosine …

Glycoside hydrolase family 77 (GH77) belongs to the α-amylase superfamily (Clan H)
together with GH13 and GH70. GH77 enzymes are amylomaltases or 4-α …

Spontaneous protein deamidation of labile Asn residues, generating l‐isoaspartates and d‐
aspartates, is associated with cell aging and is enhanced by an oxidative microenvironment; …

Every asparagine in every protein undergoes nonenzymatic deamidation to aspartate or
isoaspartate at a rate determined by the surrounding protein structure and cellular …

Determination of pK a values of titrating residues in proteins provides a direct means of
studying electrostatic coupling as well as pH-dependent stability. The B1 domain of protein …