Pharmacological neuroprotection for glaucoma

G Chidlow, JPM Wood, RJ Casson - Drugs, 2007 - Springer
Glaucoma represents a group of neurodegenerative diseases characterised by structural
damage to the optic nerve and slow, progressive death of retinal ganglion cells (RGCs) …

What are the biomarkers for glaucoma?

O Golubnitschaja, J Flammer - Survey of ophthalmology, 2007 - Elsevier
A biomarker is a parameter that can objectively be measured and evaluated as an indicator
of either normal or pathologic processes, or of a response to therapeutic intervention …

Longitudinal evaluation of retinal ganglion cell function and IOP in the DBA/2J mouse model of glaucoma

M Saleh, M Nagaraju, V Porciatti - … ophthalmology & visual …, 2007 - iovs.arvojournals.org
purpose. To characterize progressive changes of retinal ganglion cell (RGC) function and
intraocular pressure (IOP) in the DBA/2J mouse model of spontaneous glaucoma. methods …

Growth and trophic factors, pH and the Na+/H+ exchanger in Alzheimer's disease, other neurodegenerative diseases and cancer: new therapeutic possibilities and …

S Harguindey, SJ Reshkin, G Orive… - Current Alzheimer …, 2007 - ingentaconnect.com
Abnormalities in the intricate intracellular signalling pathways play a key role in the
deregulation of either spontaneous (normal or pathological) or induced (therapeutic) cell …

Alteration of retinal intrinsic survival signal and effect of α2–adrenergic receptor agonist in the retina of the chronic ocular hypertension rat

HS Kim, YI Chang, JH Kim, CK Park - Visual neuroscience, 2007 - cambridge.org
The purpose of this study is to examine the retinal expression of intrinsic cell survival
molecules and to elucidate the effect of an α2-adrenergic receptor agonist in the chronic …

Aging modifies brain region-specific vulnerability to experimental oxidative stress induced by low dose hydrogen peroxide

NA Crivello, IH Rosenberg, B Shukitt-Hale, D Bielinski… - Age, 2007 - Springer
Our previous studies demonstrated a significant decline in brain function and behavior in
Fischer 344 (F344) rats with age. The present study was designed to test the hypothesis that …