A number of factors have been implicated in the pathogenesis of cell death in Parkinson's
disease (PD). These include oxidative stress, mitochondrial dysfunction, inflammation …

Glaucoma is an insidiously progressive optic neuropathy which affects nearly 90 million
people worldwide, and is the leading cause of irreversible blindness. 1–3 It is a …

We and other workers found markedly increased levels of proinflammatory cytokines and
apoptosis-related proteins in parkinsonian brain. Although the pathogenesis of Parkinson's …

Mutations in DJ‐1 lead to early onset Parkinson's disease (PD). The aim of this study was to
elucidate further the underlying mechanisms leading to neuronal cell death in DJ‐1 …

Mutations in the gene coding for leucine-rich repeat kinase 2 (LRRK2) cause autosomal-
dominant Parkinson's disease. The pathological mutations have been associated with an …

Apoptosis of nigral dopaminergic neurons by various mechanisms is an emerging
phenomenon involved in the degeneration of dopaminergic neurons in Parkinson's disease …

In the present study, we evaluated the effect of melatonin, a well‐known free radical
scavenger and neuroprotector, against rotenone‐induced oxidative stress in a …

Parkinson's disease (PD) is a progressive neurodegenerative, dopamine deficiency
disorder. The main therapeutic strategies for PD treatment relies on dopamine precursors …

Oxidative stress and apoptotic cell death have been implicated in the dopaminergic cell loss
that characterizes Parkinson's disease. While factors contributing to apoptotic cell death are …

To evaluate the contribution of NF-κB and the NF-κB target gene p53 to nigral dopaminergic
neuron degeneration in rodent models of Parkinson's disease, time-course of dopaminergic …