Selective serotonin reuptake inhibitors (SSRIs) are utilized in the treatment of depression in
pregnant and lactating women. SSRIs may be passed to the fetus through the placenta and …

Dysregulation of brain serotonin transmission is an important contributing factor in many
psychiatric disorders. Tryptophan hydroxylase (TPH), the rate limiting enzyme in the …

Various studies provide consistent evidence for a genetic component in suicidal behavior.
First molecular genetic studies concentrated on genes of the serotonergic system based on …

BACKGROUND: Tryptophan hydroxylase 2 (TPH2) is the rate-limiting enzyme in brain
serotonin (5-HT) biosynthesis. Although dysfunction of 5-HT neurotransmission has been …

Context A small subset of patients with depression exhibit new or worsening suicidal
thoughts or behavior during short-term treatment with antidepressants. Because cyclic …

Context The tryptophan hydroxylase 2 (TPH2) gene encodes the first (also the rate-limiting)
enzyme in the serotonin biosynthetic pathway. Despite reports of possible associations …

Abstract Tryptophan hydroxylase isoform 2 (TPH2) is expressed in serotonergic neurons in
the raphe nuclei, where it catalyzes the rate-limiting step in the synthesis of the …

BACKGROUND: Suicide and depressive disorders are strongly associated, yet not all
depressed patients commit suicide. Genetic factors may partly explain this difference. We …

Genetic factors have been associated with the vulnerability to suicidal behavior. We
previously reported decisionmaking impairment in suicide attempters and hypothesized …

BACKGROUND: Bipolar affective disorder (BPAD) is a common mental illness that is
strongly associated with suicide. Suicidal behavior is thought to result from an interaction of …