NKG2D (natural-killer group 2, member D) is a powerful activating receptor expressed by
natural killer (NK) cells and T cells that regulates immune responses during infection, cancer …

A recent workshop discussed the recognition of multiple distinct ligands by individual T cell
and B cell receptors and the implications of this discovery for lymphocyte biology. The …

Summary αβ T cell receptors (TCRs) can crossreact with both self-and foreign-major
histocompatibility complex (MHC) proteins in an enigmatic phenomenon termed …

The outcome of an encounter between a cytotoxic cell and a potential target cell depends on
the balance of signals from inhibitory and activating receptors. Natural Killer group 2D …

The CD94-NKG2 receptor family that regulates NK and T cells is unique among the lectin-
like receptors encoded within the natural killer cell complex. The function of the CD94-NKG2 …

The human C-type lectin-like molecule CLEC-2 is expressed on the surface of platelets and
signaling through CLEC-2 causes platelet activation and aggregation. CLEC-2 is a receptor …

MHC-encoded molecules govern adaptive immune responses by presenting peptides to T
cell receptors (TCRs). Based on TCR–MHC crystal structures, we revisit the extent of TCR …

Multidrug resistance transporters P‐glycoprotein/ABCB1 and ABCG2 limit the effect of a
large number of cytostatic and cytotoxic drugs by energy‐dependent efflux. In experimental …

The thermodynamics of biological interactions is frequently studied by the van't Hoff analysis
whereby data on variation of the binding constant KD with temperature are used to obtain …

MICA is a major histocompatibility complex-like protein that undergoes a structural transition
from disorder to order upon binding its immunoreceptor, NKG2D. We redesigned the …