Recently, the role of transcriptional repression through epigenetic modulation in
carcinogenesis has been clinically validated with several inhibitors of histone deacetylases …

Histone deacetylase (HDAC) inhibitors such as valproic acid (VPA) induce the expression of
quiescent proviral human immunodeficiency virus type 1 (HIV-1) and may deplete proviral …

The establishment of HIV proviral latency requires the creation of repressive chromatin
structures that impair the initiation of transcription and restrict RNAP II elongation. We have …

In light of a recent report that short-term treatment with valproic acid (VA) might accelerate
the decay of the latent reservoir for HIV-1 in patients receiving combination therapy and …

Protein acetylation, catalyzed by the opposing activities of histone deacetylases (HDAC) and
histone acetyltransferases, is now recognized to be an important epigenetic modulator of …

Human Immunodeficiency Virus type 1 (HIV-1) infection can now be treated effectively in
many patients in the developed world, using combinations of antiretroviral therapeutics …

Integrated retroviral DNA is subject to epigenetic gene silencing, but the viral and host cell
properties that influence initiation, maintenance, and reactivation are not fully understood …

Chronic hepatitis C virus (HCV) infection is a major burden on humanity. The current HCV
therapy has limited efficacy, and there is pressing need for new and more effective …

The course of HIV infection is arrested by antiretroviral therapy (ART). However, life-long
ART is undesirable. To eradicate infection, strategies are needed to deplete the rare …

Publisher Summary This chapter explores the definition and mechanism of the latent
reservoir, its resistance and treatment implications, and the impact of the latent reservoir on …