Synapses need to encode a wide dynamic range of action potential frequencies. Essential
vesicle priming proteins of the Munc13 (mammalian Unc13) family play an important role in …

Before transmitter-filled synaptic vesicles can fuse with the plasma membrane upon
stimulation they have to be primed to fusion competence. The regulation of this priming …

Recruitment of release-ready vesicles at synapses is one of the important factors, which
determine dynamic properties of signaling between neurons in the brain. It has been shown …

Activity-dependent enhancement of transmitter release is a common form of presynaptic
plasticity, but the underlying signaling mechanisms have remained largely unknown …

The vesicle priming protein Munc13-1 is regulated by diacylglycerol (DAG) and is therefore
hypothesized to play a role in the control of neurotransmitter release by phospholipase C …

Calcium ion is required at various concentrations for vesicular recycling in the presynaptic
terminal. Although calmodulin (CaM) is the most abundant Ca2+-binding protein and has a …

The size of the readily releasable pool (RRP) of vesicles was measured in control conditions
and during post‐tetanic potentiation (PTP) in a large glutamatergic terminal called the calyx …

High frequency afferent stimulation of chemical synapses often induces short‐term
increases in synaptic efficacy, due to increased release probability and/or increased supply …

Background Volatile general anesthetics inhibit neurotransmitter release by an unknown
mechanism. A mutation in the presynaptic soluble NSF attachment protein receptor …

Exocytosis of insulin vesicles in the pancreatic β‐cell involves a sequence of regulated
events, whose normal function and efficient adaptation to increased demand are essential …