Congenital obstructive nephropathy is the primary cause of end-stagerenal disease in
children. Rapid diagnosis and initiation of the treatment are vital to preserve function and/or …

Urinary tract obstruction during renal development leads to tubular apoptosis, tubular
atrophy, and interstitial fibrosis. Epithelial to mesenchymal transition (EMT) has been …

Because endothelial nitric-oxide synthase (eNOS) is generally considered protective against
renal injury, we examined eNOS knockout mice for kidney pathology. In 80% of the adults …

Ureteropelvic junction obstruction is a common cause of congenital obstructive nephropathy.
To study the pathogenesis of nephropathy, a variable-partial, complete or a sham unilateral …

Renal interstitial fibrosis contributes to the progression of most chronic kidney diseases and
is an important pathologic feature of urinary tract obstruction. To study the origin of this …

Obstruction of the urinary tract activates apoptotic pathways in collecting duct cells and leads
to loss of renal parenchyma before surgical intervention. It has been suggested that …

OBJECTIVE To examine the participation of NHE1 in the regulation of the apoptotic
response in neonatal obstruction, as the ubiquitously expressed NHE1 isoform is an …

Obstructive nephropathy constitutes a major cause of renal impairment in children. Chronic
unilateral ureteral obstruction (UUO) impairs maturation of the developing kidney and leads …

Chronic unilateral ureteral obstruction (UUO) in the neonatal rat causes delayed renal
maturation, tubular apoptosis, and interstitial inflammation. Vascular endothelial growth …

Caveolae are plasma membrane invaginations that contain a variety of signal transduction
molecules and receptors for growth factors and cytokines. This study was performed to …