Abstract von Hippel‐Lindau (VHL) disease is a dominantly inherited familial cancer
syndrome resulting from mutations in the VHL tumor suppressor gene. VHL disease displays …

Objective: This pilot study was designed to provide preliminary data concerning the safety
and efficacy of pegylated anti-vascular endothelial growth factor (VEGF) therapy …

Objectives To characterize the germline mutations found in a large population of persons
having von Hippel-Lindau (VHL) disease mutations with the clinical characteristics of …

Over the last decade there have been rapid advances in our knowledge about the molecular
basis of many inherited disorders. Molecular testing is now available for many conditions …

Haemangioblastomas of the CNS are a cardinal feature of von Hippel–Lindau (VHL)
disease, a dominantly inherited multisystem familial cancer syndrome caused by germline …

The familial forms of pheochromocytoma have recently been demonstrated to be more
frequent than believed in the past. The genes currently known to be responsible for tumor …

Objective Spinal cord hemangioblastoma is an uncommon vascular neoplasm with a benign
nature and is associated with von Hippel-Lindau (VHL) disease in 20-30% of patients. Total …

The current clinical diagnosis of Von Hippel‐Lindau (VHL) disease demands at least one
specific a sporadic VHL manifestation in a patient with familial VHL disease, or, in asporadic …

Clear cell renal cell carcinoma (ccRCC) is the most common malignant neoplasm of the
kidney. The majority of hereditary and sporadic ccRCC cases are associated with germline …

OBJECTIVES: To evaluate the risks of local recurrence and repeat surgery after nephron-
sparing surgery (NSS) in von Hippel-Lindau (VHL) disease to propose a therapeutic strategy …