Two fundamental principles can account for how regulated networks of interacting proteins
originated in cells. These are the law of mass action, which holds that the binding of one …

The energetic profiles of a significant number of protein–DNA systems at 20° C reveal that,
despite comparable Gibbs free energies, association with the major groove is primarily an …

Context: Mutations in the transcription factor HESX1 have previously been described in
association with septooptic dysplasia (SOD) as well as isolated defects of the hypothalamic …

Short stature due to SHOX deficiency represents a common congenital form of growth failure
and is involved in the aetiology of 'idiopathic'short stature and the growth deficits and …

A common task posed by microarray experiments is to infer the binding site preferences for a
known transcription factor from a collection of genes that it regulates and to ascertain …

Abstract The Short Stature Homeobox-containing Gene SHOX was identified as the genetic
cause of the short stature phenotype in patients with Turner Syndrome and in certain …

Pax6 transcription is under the control of two main promoters (P0 and P1), and these are
autoregulated by Pax6. Additionally, Pax6 expression is under the control of the TGFβ …

Pancreatic and duodenal homeobox 1 (Pdx1) is a homeodomain transcription factor
belonging to the ParaHox family. Pdx1 plays an essential role in pancreatic endocrine and …

PAX3 or PAX3-FKHR expression is implicated in cell transformation and tumourigenesis.
Here, C2C12 myoblasts were transfected with a sense Pax3 vector and a pTet-On system to …

Pax3 is a transcription factor that plays an important role during neurogenesis and
myogenesis, and Pax3 mutant animals display neural tube defects and lack limb muscles …