A better understanding of the molecular biology of renal cell carcinoma (RCC) has led to a
dramatic paradigm shift in the treatment of patients with metastatic disease. Historically, a …

Tumor hypoxia is related to tumor progression and therapy resistance, which leads to poor
patient outcome. It has been suggested that measuring the hypoxic status of a tumor helps to …

Abstract Purpose: Hypoxia-inducible factor-1α (HIF-1α) plays an important role in tumoral
adaptation to hypoxic conditions by serving as a transcription factor for several crucial …

Purpose Expression of carbonic anhydrase IX (CAIX) has been reported to be an
independent predictor of outcome and is being investigated as a therapeutic target for …

Purpose Similar to other molecularly targeted agents, temsirolimus, an inhibitor of
mammalian target of rapamycin, has shown promising activity in advanced renal cell …

OBJECTIVE To evaluate the prognostic information of carbonic anhydrase (CA) IX
expression in patients with renal cell carcinoma (RCC), as increased expression of CA IX is …

Inhibitors of the mammalian target of rapamycin (mTOR) have shown promising efficacy in
early-stage trials in patients with advanced renal cell carcinoma (RCC). Most RCCs have …

PURPOSE: Hypoxia adversely relates with prognosis in human tumours. Five hypoxia
specific predictive marker assays were compared and correlated with definitive …

PURPOSE: Sarcomatoid renal cell carcinomas, highly aggressive variants of renal cell
carcinoma subtypes, often present with or develop metastases soon after the primary …

Recent progress in understanding the role of catalytically active carbonic anhydrases in
tumors has opened new possibilities for diagnostic and/or therapeutic applications of …