Cocaine addicts increase the frequency and amount of drug use over time. This
characteristic has been modeled by escalating drug intake in rats that were given extended …

Increased drug availability can precipitate a rapid transition to compulsive drug use in both
vulnerable humans and laboratory animals. Recent studies have shown that despite …

It has been proposed that some neuroadaptations that underlie behavioral sensitization may
play a role in the development and persistence of addiction. However, whether or not …

Exposure to repeated, intermittent, escalating doses of amphetamine in rats disrupts
information processing in several tasks. Some of these deficits, notably impaired attentional …

We previously reported that brief (1 h), but not extended (6 h), daily access to cocaine results
in a sensitized locomotor response to cocaine and in elevated c-Fos immunoreactivity and …

Rationale Escalation from moderate to excessive drug intake is a hallmark of human
addiction that can be modeled in rats by giving them longer daily access time to self …

Rats selectively bred for high saccharin consumption (HiS) self-administer more oral ethanol
and iv cocaine than those selectively bred for low saccharin consumption (LoS). Male and …

This study examined the effects of simultaneous variations in motivational state (food
deprivation) and reinforcer magnitude (food presentation) on c-Fos immunoreactivity in the …

Introduction of local circuitry, consisting of vast networks of neuronal cells. The human brain
is composed of billions of interconnected neurons and contains even more neuron …

Universidad Nacional Autónoma de México Facultad de Estudios Superiores Iztacala Page 1
0 Universidad Nacional Autónoma de México Facultad de Estudios Superiores Iztacala “Familias …