In our quest to understand why dimethyl sulfoxide (DMSO) can cause growth arrest and
terminal differentiation of transformed cells, we followed a path that led us to discover …

The path to the discovery of suberoylanilide hydroxamic acid (SAHA, vorinostat) began over
three decades ago with our studies designed to understand why dimethylsulfoxide causes …

A cancer develops when a cell acquires specific growth advantages through the stepwise
accumulation of heritable changes in gene function. Basically, this process is directed by …

Sulforaphane, an isothiocyanate found in cruciferous vegetables, has been shown to induce
phase 2 detoxication enzymes and inhibit the growth of chemically induced mammary …

Purpose To determine the safety, toxicity, and maximum-tolerated dose of a sequence-
specific combination of the histone deacetylase inhibitor (HDACi), valproic acid (VPA), and …

Histones are a family of nuclear proteins that interact with DNA, resulting in DNA being
wrapped around a core of histone octamer within the nucleosome. Acetylation/deacetylation …

Valproic acid (VPA) has been used as an anticonvulsant for decades. Recently, it was
demonstrated that VPA also acts as a histone deacetylase inhibitor and induces …

Purpose: The molecular chaperone heat shock protein (hsp)-90 maintains estrogen receptor
(ER)-α in an active conformation, allowing it to bind 17β-estradiol (E2) and transactivate …

Histone deacetylases (HDACs) and histone acetyltransferases are enzymes that regulate
chromatin structure and function through the removal and addition, respectively, of the acetyl …

Constitutive activation of Akt or nuclear factor-κB (NF-κB) has been reported to play a role in
de novo resistance of cancer cells to chemotherapeutic agents, which is a major cause of …