Apoptosis has been accepted as a fundamental component in the pathogenesis of cancer,
in addition to other human diseases including neurodegeneration, coronary disease and …

The avoidance of apoptosis is one of the hallmarks of cancer cells. In addition, failure to
induce apoptosis by anticancer agents, either due to limitations of the drug or the tumour cell …

XIAP is a central apoptosis regulator that inhibits apoptosis by binding to and inhibiting the
effectors caspase-3/-7 and an initiator caspase-9 through its BIR2 and BIR3 domains …

A small series of peptide mimics was designed and synthesized to contain a heterocyclic
ring in place of the potentially labile N-terminal peptide bond of the tetrapeptide containing …

Evaluation of binding free energy in receptor− ligand complexes is one of the most important
challenges in theoretical drug design. Free energy is directly correlated to the …

Apoptosis is involved in a wide range of pathologic conditions, including neurodegenerative,
autoimmune diseases, cardiovascular diseases and cancer. Therefore, the ability to …

A large body of experimental evidence indicates that the specific molecular interactions
and/or chemical conversions depicted as links in the conventional diagrams of cellular …

Target‐assisted iterative screening (TAIS) has been applied to a random phage‐displayed
peptide library in a search for novel ligands of the third b aculovirus I AP ('inhibitors of …

XIAP (X-linked inhibitor of apoptosis protein) is involved in the mediation of programmed cell
death and, therefore, is a target for the development of cancer therapeutics. Peptide …

蛋白质-蛋白质相互作用在细胞活动和生命过程中扮演着非常重要的角色. 基因调节, 免疫应答,
信号转导, 细胞组装等等都离不开蛋白质-蛋白质的相互作用. 近几年, 靶向蛋白质 …