An association between multiple sclerosis (MS) and the human leukocyte antigen (HLA)
complex, a dense cluster of genes on the short arm of chromosome 6, was first noted over …

The most important confirmed genetic factor of susceptibility to multiple sclerosis (MS) has
been identified in the HLA class II region. The hypothesis that several genes, including HLA …

Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system
unsurpassed for variability in disease outcome. A cohort of sporadic MS cases (n= 163) …

Background: Familial factors influence susceptibility to multiple sclerosis (MS) but it is
unknown whether there are additional effects on the natural history of the disease. Method …

Background It has been suggested that coeliac disease (CD) is associated with several
neurological diseases. However, the evidence of such an association is inconclusive as …

The human leucocyte antigen (HLA) class II haplotype DRB1* 15–DQB1* 06 (DR15–DQ6) is
associated with susceptibility to multiple sclerosis (MS), and HLA class I associations in MS …

BACKGROUND: The association between susceptibility to multiple sclerosis (MS) and HLA-
DRB1⁎ 15 has been reported in various European populations. OBJECTIVE: To investigate …

Although several therapies exist for multiple sclerosis (MS), the most common inflammatory
demyelinating disease of the central nervous system (CNS), there remains a large unmet …

Background Multiple sclerosis (MS) is consistently associated with particular HLA-DRB1-
DQB1 haplotypes. However, existing evidence suggests that variation at these loci does not …

The enormous development in the field of molecular genetics during the last decades has
lead to optimism concerning the possibilities for identifying the causes of multiple sclerosis …