The CYP51 family is an intriguing subject for fundamental P450 structure/function studies
and is also an important clinical drug target. This review updates information on the variety …

This review discusses the challenges of chemotherapy for human African trypanosomiasis
(HAT). The few drugs registered for use against the disease are unsatisfactory for a number …

Leishmania parasites cause a broad spectrum of clinical disease. Here we report the
sequencing of the genomes of two species of Leishmania: Leishmania infantum and …

Primary cilia play critical roles in many aspects of biology. Specialized versions of primary
cilia are involved in many aspects of sensation. The single photoreceptor sensory cilium …

Dyneins are large minus‐end‐directed microtubule motors. Each dynein contains at least
one dynein heavy chain (DHC) and a variable number of intermediate chains (IC), light …

This paper describes the application of the Nucleofector system for transient and stable
transfection of bloodstream and procyclic forms of Trypanosoma brucei, and its comparison …

The calpain family is named for the calcium dependence of the papain-like, thiol protease
activity of the well-studied ubiquitous vertebrate enzymes calpain-1 (μ-calpain) and calpain …

Eukaryotic cilia and flagella are motile organelles built on a scaffold of doublet microtubules
and powered by dynein ATPase motors. Some thirty years ago, two competing views were …

Eimeria species infect livestock in a host-specific manner and are the cause of the disease,
coccidiosis. Control of Eimeria species is essential and is currently dominated by …

The complete analysis of the genomes of three major trypanosomatid parasites has
facilitated comparison of the metabolic capabilities of each, as predicted from gene …