During the past 15 years, most large pharmaceutical companies have decreased the
screening of natural products for drug discovery in favor of synthetic compound libraries …

Computer-based analysis revealed that natural products exhibit a remarkable structural
diversity of molecular frameworks and scaffolds that could be systematically exploited for …

Natural product substances have historically served as the most significant source of new
leads for pharmaceutical development. However, with the advent of robotics, bioinformatics …

Natural compounds are evolutionary selected and prevalidated by Nature, displaying a
unique chemical diversity and a corresponding diversity of biological activities. These …

Cheminformatic methods allow the detailed characterization of particular and characteristic
properties of natural products (NPs) and comparison with related characteristics of drugs …

Ethnopharmacology is a very interesting resource in which new therapies may be
discovered. In the case of malaria, two major antimalarial drugs widely used today came …

The access to libraries of molecules with interesting biomolecular properties is a limiting
step in the drug discovery process. By virtue of a long molecular evolution process, natural …

The main aspects of the modern Medicinal Chemistry, among the classic and industrial
paradigms, used in the drug discovery process will be treated. The contribution of the …

This paper presents an overview of the Natural Products Research in Brazil in the last five
years (2002-2006), and also discusses how some relevant aspects of the Chemical Biology …

The underlying frameworks of natural product classes with multiple biological activities can
be regarded as biologically selected and prevalidated starting points in vast chemical …