The objective of this study is to evaluate the activity of a novel peptide, ie, bifunctional
peptide inhibitor (BPI), which targets the immunological synapse and inhibits autoimmune …

Influenza A virus infection of C57BL/6 mice is a well-characterized model for studying CD8+
T cell-mediated immunity. Analysis of primary and secondary responses showed that the …

The liver holds a unique position with regard to the blood circulation. It receives venous
blood draining from almost the entire gastrointestinal tract via the portal vein and from the …

Tolerance induction to prevent activation of a naïve T‐cell repertoire has been well
documented in rodents and can be readily achieved by intravenous, oral or intranasal …

Injection of soluble foreign antigen without an adjuvant induces a state of antigen‐specific
immunological unresponsiveness. We investigated the cellular mechanisms that underlie …

The deletion of CD4‐and CD8‐double‐positive (DP) cells in the thymus after treatment with
anti‐CD3 antibodies has long been considered as a useful model for clonal deletion during …

Chronic kidney disease (CKD) is the ninth leading cause of death in the United States.
According to the National Kidney Foundation, more than 20 million people already have …

The increased incidence of allergic diseases is a widely recognized health problem in
industrialized countries. Since the role of T cells, particularly T helper type 2 (Th2) cells, in …

Dendritic cells can present exogenous antigen to CD8 T cells using a mechanism termed
cross-presentation. This mechanism is important for immune responses against tumors …

The default pathway for developing thymocytes is apoptosis they must be actively instructed
to survive and proliferate. Approximately 95% of developing thymocytes undergo apoptosis …