The transient receptor potential (TRP) superfamily consists of a large number of cation
channels that are mostly permeable to both monovalent and divalent cations. The 28 …

The progression of cells from a normal differentiated state in which rates of proliferation and
apoptosis are balanced to a tumorigenic and metastatic state involves the accumulation of …

In recent years, the transient receptor potential melastatin member 8 (TRPM8) channel has
emerged as a promising prognostic marker and putative therapeutic target in prostate …

Ion channels are involved in normal physiologic processes and in the pathology of various
diseases. In this study, we investigated the presence and potential function of transient …

Cancer is the second most common cause of death in western countries. It is therefore of
fundamental importance to improve the treatment of patients with malignant tumors. This …

Plasma membrane ion channels contribute to virtually all basic cellular processes, including
such crucial ones for maintaining tissue homeostasis as proliferation, differentiation, and …

Originally cloned as a prostate-specific protein, TRPM8 is now best known as a cold-and
menthol-activated channel implicated in thermosensation. In this chapter we provide a brief …

Predicting prognosis in prostate carcinoma remains a challenge when using clinical and
pathologic criteria only. We used an array-based DASL® assay to identify molecular …

One of the best-studied temperature-gated channels is transient receptor potential
melastatin 8 (TRPM8), which is activated by cold and cooling agents, such as menthol …

Many human diseases are caused by mutations in ion channels. Dissecting the
pathogenesis of these 'channelopathies' has yielded important insights into the regulation of …