Abstract Heat shock protein 90 (Hsp90) is a molecular chaperone required for the stability
and function of a number of conditionally activated and/or expressed signaling proteins, as …

Heat shock protein 90 (Hsp90) is a molecular chaperone required for the stability and
function of several conditionally activated and/or expressed signaling proteins as well as …

Purpose This phase I study examined whether a heat shock protein (Hsp) 90 inhibitor
tanespimycin (17-AAG; KOS-953) could be administered safely in combination with …

Purpose: To define the maximum tolerated dose (MTD), toxicities, and pharmacokinetics of
17-allylamino-17-demethoxygeldanamycin (17-AAG) when administered using continuous …

Motor neuron degeneration resulting from the aggregation of the androgen receptor with an
expanded polyglutamine tract (AR-polyQ) has been linked to the development of spinal and …

The promising antitumor activity of 17-allylamino-17-demethoxygeldanamycin (17AAG)
results from inhibition of the molecular chaperone heat shock protein 90 (HSP90) and …

Stress or heat shock proteins (Hsps) Hsp90, Hsp70 and Hsp27 are chaperones that assist
the proteins in their folding, stability, assembly into multi-protein complexes and transport …

Selective hsp90 inhibitors simultaneously destabilize and deplete key signaling proteins
involved in cell proliferation and survival, angiogenesis, and metastasis. Investigation of …

Growth of prostate cancer cells is initially dependent on androgens, and androgen ablation
therapy is used to control tumor growth. Unfortunately, resistance to androgen ablation …

Purpose: To determine the recommended phase 2 dose, dose-limiting toxicities (DLT),
pharmacokinetic profile, and pharmacodynamics of the heat shock protein (Hsp) 90 inhibitor …