Over the past five years, the importance of a diverse class of 18–24 nucleotide RNA
molecules, known as microRNAs (miRNAs) has increasingly been recognized. These highly …

MicroRNAs are a recently discovered class of small, evolutionarily conserved, RNA
molecules that negatively regulate gene expression at the post-transcriptional level. Mature …

Summary p53 is a potent tumor suppressor, whose biological effects are largely due to its
function as a transcriptional regulator. Here we report that, in addition to regulating the …

The activity and safety of the histone deacetylase inhibitor vorinostat (suberoylanilide
hydroxamic acid, SAHA) were evaluated in patients with refractory cutaneous T-cell …

MicroRNAs (miRNAs) are potent post‐transcriptional regulators of protein coding genes.
Patterns of misexpression of miRNAs in cancer suggest key functions of miRNAs in …

Pancreatic cancer is a disease with an extremely poor prognosis. Tumor protein 53-induced
nuclear protein 1 (TP53INP1) is a proapoptotic stress-induced p53 target gene. In this …

The insulin receptor substrate-1 (IRS-1), a docking protein for both the type 1 insulin-like
growth factor receptor (IGF-IR) and the insulin receptor, is known to send a mitogenic, anti …

The childhood eye cancer retinoblastoma is initiated by the loss of both alleles of the
prototypic tumor suppressor gene, RB1. However, a large number of cytogenetic and …

New Zealand black (NZB) mice with autoimmune and B lymphoproliferative disease (B-LPD)
are a model for human chronic lymphocytic leukemia (CLL). A genomewide linkage scan of …

Oxygen is both an environmental and developmental signal that governs important cellular
pathways. Therefore, hypoxia (or low oxygen tensions) is part of both physiological and …