Safety considerations with fibrate therapy
MH Davidson, A Armani, JM McKenney… - The American journal of …, 2007 - Elsevier
Fibrates are an important class of drugs for the management of dyslipidemia. This class of
drugs is generally well tolerated but is infrequently associated with several safety issues …
drugs is generally well tolerated but is infrequently associated with several safety issues …
PPARs in the brain
MT Heneka, GE Landreth - Biochimica et biophysica acta (BBA)-molecular …, 2007 - Elsevier
The biology of peroxisome proliferator activated receptors (PPARs) in physiological and
pathophysiological processes has been primarily studied in peripherial organs and tissues …
pathophysiological processes has been primarily studied in peripherial organs and tissues …
PPARγ in human and mouse physiology
S Heikkinen, J Auwerx, CA Argmann - … (BBA)-Molecular and Cell Biology of …, 2007 - Elsevier
The peroxisome proliferator activated receptor gamma (PPARγ) is a member in the nuclear
receptor superfamily which mediates part of the regulatory effects of dietary fatty acids on …
receptor superfamily which mediates part of the regulatory effects of dietary fatty acids on …
PPARα in atherosclerosis and inflammation
F Zandbergen, J Plutzky - Biochimica et Biophysica Acta (BBA)-Molecular …, 2007 - Elsevier
Peroxisome proliferator-activated receptor (PPAR) α is a nuclear receptor activated by
natural ligands such as fatty acids as well as by synthetic ligands such as fibrates currently …
natural ligands such as fatty acids as well as by synthetic ligands such as fibrates currently …
Statins activate peroxisome proliferator-activated receptor γ through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase–dependent …
M Yano, T Matsumura, T Senokuchi, N Ishii… - Circulation …, 2007 - Am Heart Assoc
Both statins and peroxisome proliferator-activated receptor (PPAR) γ ligands have been
reported to protect against the progression of atherosclerosis. In the present study, we …
reported to protect against the progression of atherosclerosis. In the present study, we …
Diabetes mellitus and macrovascular disease: mechanisms and mediators
PJ Boyle - The American journal of medicine, 2007 - Elsevier
Atherosclerosis is a chronic inflammatory condition initiated in the endothelium in response
to injury and maintained through the interactions between modified lipoproteins …
to injury and maintained through the interactions between modified lipoproteins …
PPARs and their metabolic modulation: new mechanisms for transcriptional regulation?
W Ahmed, O Ziouzenkova, J Brown… - Journal of internal …, 2007 - Wiley Online Library
Peroxisome proliferator‐activated receptors (PPARs) as ligand‐activated nuclear receptors
involved in the transcriptional regulation of lipid metabolism, energy balance, inflammation …
involved in the transcriptional regulation of lipid metabolism, energy balance, inflammation …
PPARs and the placenta
T Fournier, V Tsatsaris, K Handschuh, D Evain-Brion - Placenta, 2007 - Elsevier
The discovery of the peroxisome proliferator-activated receptors (PPARs) in 1990s provided
new insights in understanding the mechanisms involved in the control of energy …
new insights in understanding the mechanisms involved in the control of energy …
Dietary n-3 PUFA deprivation for 15 weeks upregulates elongase and desaturase expression in rat liver but not brain
M Igarashi, K Ma, L Chang, JM Bell, SI Rapoport - Journal of lipid research, 2007 - ASBMB
Fifteen weeks of dietary n-3 PUFA deprivation increases coefficients of conversion of
circulating α-linolenic acid (α-LNA; 18: 3n-3) to docosahexaenoic acid (DHA; 22: 6n-3) in rat …
circulating α-linolenic acid (α-LNA; 18: 3n-3) to docosahexaenoic acid (DHA; 22: 6n-3) in rat …
PPARγ‐dependent regulation of human macrophages in phagocytosis of apoptotic cells
Macrophages acquire their capacity for efficient phagocytosis of apoptotic cells during their
differentiation from monocytes. The peroxisome proliferator‐activated receptor gamma …
differentiation from monocytes. The peroxisome proliferator‐activated receptor gamma …