Subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) are constructed from
numerous subunit combinations that compose channel-receptor complexes with varied …

The amyloid Aβ-peptide (Aβ) is suspected to play a critical role in the cascade leading to AD
as the pathogen that causes neuronal and synaptic dysfunction and, eventually, cell death …

Nicotinic acetylcholine receptors play important roles in numerous cognitive processes as
well as in several debilitating central nervous system (CNS) disorders. In order to fully …

The first edition of this book, Chemical Warfare Agents: Toxicity at Low Levels, was
published just prior to the terrorist attacks of September 11th, 2001. Reflecting a greater …

Studies in cell culture and in animals suggest that neuregulin 1 (NRG1), a probable
schizophrenia susceptibility gene, regulates the expression of the α7 nicotinic acetylcholine …

Nicotinic acetylcholine receptors (nAChRs) represent a class of therapeutic targets with the
potential to impact numerous diseases and disorders where significant unmet medical …

Galantamine is an approved treatment for mild to moderate Alzheimer's disease, with
demonstrated benefits for cognition and functional ability in human studies. The mechanism …

目的研究β-淀粉样蛋白(Aβ1~ 42) 对大鼠大脑神经型尼古丁受体α7 亚单位表达及学习记忆能力
的影响, 探讨这些改变在阿尔茨海默病(AD) 发病机制中的作用. 方法用立体定向法将Aβ1~ 42 …

The pathogenesis of Alzheimer's disease (AD), the most common of the neurodegenerative
disorders, is likely to involve a number of different processes. Oxidative stress and deficits in …

The key pathogenic event in the onset of Alzheimer's disease (AD) is the aggregation of β-
amyloid (Aβ) peptides into toxic aggregates. Molecules that interfere with this process may …