The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

Accumulating evidence suggests that the reactive oxygen and nitrogen species are
generated in cardiomyocytes and endothelial cells during myocardial ischemia/reperfusion …

Diatomic ligand discrimination by soluble guanylyl cyclase (sGC) is paramount to
cardiovascular homeostasis and neuronal signaling. Nitric oxide (NO) stimulates sGC …

Since the discovery of atrial natriuretic factor by de Bold et al., there has been tremendous
progress in our understanding of the physiologic, diagnostic and therapeutic roles of the …

Pathological stress from cardiovascular disease stimulates hypertrophy of heart cells, which
increases the risk of cardiac morbidity and mortality. Recent evidence has indicated that …

Reactive oxygen and nitrogen species have been implicated in diverse subcellular activities,
including cell proliferation, differentiation and, in some instances, cell injury and death. The …

Soluble guanylate cyclase is a heterodimeric enzyme with a prosthetic heme group that, on
binding of its main ligand, NO, generates the second messenger cGMP. Unlike conventional …

Rationale: Nitric oxide–independent agonists of soluble guanylate cyclase (sGC) have been
developed. Objectives: We tested whether inhalation of novel dry-powder microparticle …

The nitric oxide (NO)–soluble guanylate cyclase (sGC)‐cyclic 3′, 5′‐guanosine
monophosphate (cGMP) pathway plays an important role in cardiovascular regulation by …

Pulmonary vasoconstriction is believed to be an early component of pulmonary arterial
hypertension. Intracellular calcium concentration ([Ca2+] i) is a major trigger for pulmonary …