The molecular target of rapamycin (mTOR) is central to a complex intracellular signaling
pathway and is involved in diverse processes including cell growth and proliferation …

Abstract Takayasu's arteritis (TA), a rare large vessel vasculitis of unknown aetiology,
remains a difficult disease to manage with diagnosis often delayed until the late occlusive …

Background—We investigated the potential of conversion to sirolimus (SRL) as a primary
immunosuppressant in attenuating cardiac allograft vasculopathy progression. Methods and …

Cardiac transplantation is the most effective treatment for advanced heart failure. Despite
improvements in immunosuppression therapy that prevent acute rejection, cardiac allografts …

Interferon (IFN)-γ, a cytokine characteristically expressed in arteriosclerotic diseases, acts
directly on vascular smooth muscle cells to induce cellular proliferation and intimal …

Background Chronic hypoxia induces pulmonary arterial hypertension (PAH). Smooth
muscle cell (SMC) proliferation and hypertrophy are important contributors to the remodeling …

Retransplants comprise only a small minority (3–4%) of heart transplants, however outcome
following retransplantation is compromised. Risk factors for a poor outcome following …

Endothelial dysfunction precedes hypertension and atherosclerosis and predicts cardiac
allograft vasculopathy and death in heart transplant recipients. Endothelial overproduction of …

Background. Calcineurin-inhibitor (CNI) nephrotoxicity is a major cause of morbidity and
mortality after cardiac transplantation. The aim of this study was to assess over 2 years the …

While advances in immunosuppressive therapy have allowed dramatic improvements in the
control of acute allograft rejection, there is still a need to improve long-term graft and patient …