Thrombus formation, including platelet adhesion, activation, secretion and aggregation as
well as tissue factor-initiated thrombin generation and fibrin formation, has been studied in …

Platelets play a central role in hemostasis, but also in atherothrombosis, as they rapidly
adhere to tissue and to one another as a response to any vascular injury. This process …

Greater understanding of the cellular interactions associated with tissue factor (TF), activated
factor (F) VII and TF–FVIIa complexes is likely to provide considerable clinical benefit. This …

Microparticles are small, membrane-bound vesicles that are generated from cells of different
origin. It now appears that all circulating blood cells as well as endothelial cells release …

How platelet activation begins, and the degree to which it is essential, depends in part on
where it occurs within the circulation and why. In the venous system, low flow rates and …

The ability of platelets to provide a highly reactive surface for the recruitment of other
platelets and leukocytes to sites of vascular injury is critical for hemostasis …

In response to hemorrhage, circulating platelets adhere to exposed subendothelial tissues
and then recruit additional platelets into aggregates that function as procoagulant surfaces …

Microparticles (MPs), shed during the storage of platelets, support blood coagulation and
could be helpful in restoring the haemostatic system in thrombocytopenic patients. The …

Tissue factor (TF) is historically known as the trigger of the coagulation cascade. This
integral membrane glycoprotein forms a ternary complex with factor VIIa (FVIIa) and …

Activated clotting factors are down-regulated by two major mechanisms which involve
protease inhibitors or proteolytic degradation. To date, no down-regulating mechanism for …