The continuing problem of human African trypanosomiasis (sleeping sickness)

PGE Kennedy - Annals of Neurology: Official Journal of the …, 2008 - Wiley Online Library
Human African trypanosomiasis, also known as sleeping sickness, is a neglected disease,
and it continues to pose a major threat to 60 million people in 36 countries in sub‐Saharan …

Traversal of human and animal trypanosomes across the blood-brain barrier

DJ Grab, PGE Kennedy - Journal of Neurovirology, 2008 - Springer
The neurological complications of human African trypanosomiasis (HAT) in man caused by
the unicellular protozoan parasites Trypanosoma brucei gambiense and T. b. rhodesiense …

African trypanosomiasis: sensitive and rapid detection of the sub-genus Trypanozoon by loop-mediated isothermal amplification (LAMP) of parasite DNA

ZK Njiru, ASJ Mikosza, E Matovu, JCK Enyaru… - International journal for …, 2008 - Elsevier
Control of human African trypanosomiasis (HAT) is dependent on accurate diagnosis and
treatment of infected patients. However, sensitivities of tests in routine use are unsatisfactory …

Safety and effectiveness of first line eflornithine for Trypanosoma brucei gambiense sleeping sickness in Sudan: cohort study

G Priotto, L Pinoges, IB Fursa, B Burke, N Nicolay… - Bmj, 2008 - bmj.com
Objective To assess the safety and effectiveness of eflornithine as first line treatment for
human African trypanosomiasis. Design Cohort study. Setting Control programme in Ibba …

Development of drug resistance in Trypanosoma brucei rhodesiense and Trypanosoma brucei gambiense. Treatment of human African trypanosomiasis with natural …

S Gehrig, T Efferth - International journal of molecular …, 2008 - spandidos-publications.com
Human African trypanosomiasis is an infectious disease which has resulted in the deaths of
thousands of people in Sub-Saharan Africa. Two subspecies of the protozoan parasite …

Comparative efficacy assessment of pentamidine isethionate and diminazene aceturate in the chemotherapy of Trypanosoma brucei brucei infection in dogs

PO Akpa, RC Ezeokonkwo, CA Eze, BM Anene - Veterinary parasitology, 2008 - Elsevier
The chemotherapeutic efficacy of diminazene aceturate (Berenil®)–a standard veterinary
trypanocide and pentamidine isethionate (PMI)–a human trypanocide was compared in …

Detection of Trypanosoma brucei parasites in blood samples using real-time nucleic acid sequence-based amplification

CM Mugasa, GJ Schoone, RA Ekangu… - … and infectious disease, 2008 - Elsevier
Currently, the conventional diagnosis of human African trypanosomiasis (HAT) is by
microscopic demonstration of trypomastigotes in blood, lymph, and/or cerebrospinal fluid …

Novel Markers for Treatment Outcome in Late-Stage Trypanosoma brucei gambiense Trypanosomiasis

V Lejon, I Roger, DM Ngoyi, J Menten… - Clinical Infectious …, 2008 - academic.oup.com
Background. To date, no biological marker for treatment outcome in human African
trypanosomiasis (HAT) has been described. The accuracy of biological markers for …

Synthesis of novel benzamidine-and guanidine-derived polyazamacrocycles: Selective anti-protozoal activity for human African trypanosomiasis

CM Reid, C Ebikeme, MP Barrett, EM Patzewitz… - Bioorganic & medicinal …, 2008 - Elsevier
Efficient synthetic routes have been developed for the preparation of two new
polyazamacrocycles tagged with structural motifs recognised by the Trypanosoma brucei P2 …

Factors influencing the spread and selection of drug resistance in Human African Trypanosomiasis

AJ Nalunkuma Kazibwe - 2008 - theses.gla.ac.uk
A growing problem with drug resistance in Human African Trypanosomiasis has
necessitated the implementation of screening programmes to monitor for its spread. This …