HIV-1 protease folding and the design of drugs which do not create resistance
Human immunodeficiency virus type 1 (HIV-1) protease (PR) plays an essential role in the
life cycle of the virus. Consequently, its inhibition can control acquired immunodeficiency …
life cycle of the virus. Consequently, its inhibition can control acquired immunodeficiency …
The energy landscapes of repeat-containing proteins: topology, cooperativity, and the folding funnels of one-dimensional architectures
Repeat-proteins are made up of near repetitions of 20–to 40–amino acid stretches. These
polypeptides usually fold up into non-globular, elongated architectures that are stabilized by …
polypeptides usually fold up into non-globular, elongated architectures that are stabilized by …
Changes of protein folding pathways by circular permutation: overlapping nuclei promote global cooperativity
E Haglund, MO Lindberg, M Oliveberg - Journal of Biological Chemistry, 2008 - ASBMB
The evolved properties of proteins are not limited to structure and stability but also include
their propensity to undergo local conformational changes. The latter, dynamic property is …
their propensity to undergo local conformational changes. The latter, dynamic property is …
[HTML][HTML] Folding of a LysM domain: entropy-enthalpy compensation in the transition state of an ideal two-state folder
AA Nickson, KE Stoll, J Clarke - Journal of molecular biology, 2008 - Elsevier
Protein-engineering methods (Φ-values) were used to investigate the folding transition state
of a lysin motif (LysM) domain from Escherichia coli membrane-bound lytic murein …
of a lysin motif (LysM) domain from Escherichia coli membrane-bound lytic murein …
Denatured state is critical in determining the properties of model proteins designed on different folds
A Amatori, G Tiana, J Ferkinghoff‐Borg… - Proteins: Structure …, 2008 - Wiley Online Library
The thermodynamics of proteins designed on three common folds (SH3, chymotrypsin
inhibitor 2 [CI2], and protein G) is studied with a simplified Cα model and compared with the …
inhibitor 2 [CI2], and protein G) is studied with a simplified Cα model and compared with the …