Adenosine is a key endogenous molecule that regulates tissue function by activating four G-
protein-coupled adenosine receptors: A1, A2A, A2B and A3. Cells of the immune system …

The resistance of many human cancers to immune-based therapies, including adoptive
immunotherapy and the administration of therapeutic cancer vaccines, has been attributed …

Background Monocytes and macrophages express an extensive repertoire of G Protein-
Coupled Receptors (GPCRs) that regulate inflammation and immunity. In this study we …

Adenosine regulates the function of the innate and adaptive immune systems through
targeting virtually every cell type that is involved in orchestrating an immune/inflammatory …

The wide distribution of ATP and adenosine receptors as well as enzymes for purine
metabolism in different gut regions suggests a complex role for these mediators in the …

Although type 1 diabetes cannot be prevented or reversed, replacement of insulin
production by transplantation of the pancreas or pancreatic islets represents a definitive …

Inflammatory bowel diseases (IBDs) are chronic disorders resulting from abnormal and
persistent immune responses which lead to severe tissue injury and disturbances in …

Proliferation of vascular smooth muscle cells (VSMC), oxidative stress, and elevated
inflammatory cytokines are some of the components that contribute to plaque formation in …

In the airway epithelia, extracellular adenosine modulates a number of biological processes.
However, little is known about adenosine's role in the inflammatory responses of airway …

In immune-induced inflammation, leukocytes are key mediators of tissue damage. Since A
2A adenosine receptors (A 2A R) are endogenous suppressors of inflammation, we …