Vorinostat (suberoylanilide hydroxamic acid, SAHA) is a histone deacetylase inhibitor active
clinically in cutaneous T-cell lymphoma and preclinically in leukemia. A phase 1 study was …

The term epigenetics is defined as heritable changes in gene expression patterns that occur
without changes in DNA sequence. Epigenetic changes according to this definition are …

The discovery of new small molecules and their testing in rational combination poses an
ongoing problem for rare diseases, in particular, for pediatric cancers such as …

Abstract Background Histone deacetylase inhibitors (HDACi) are a new class of promising
anti-tumour agent inhibiting cell proliferation and survival in tumour cells with very low …

AIM: To explore the effect of trichostatin A (TSA) on apoptosis and acetylated histone H3
levels in gastric cancer cell lines BGC-823 and SGC-7901. METHODS: The effect of TSA on …

Norsolorinic acid, isolated from the Aspergillus nidulans, was investigated for its
antiproliferative activity in human breast adenocarcinoma MCF‐7 cells. To identity the …

This invention pertains to certain active carbamic acid com pounds which inhibit HDAC
activity and which have the following formula:(1) A is an aryl group; Q'is a covalent bond or …

Angiogenese ist die wichtigste Voraussetzung für das Wachstum und die
Metastasierungeines Tumors, da Sauerstoff und Nährstoffe für das Tumorgewebe …

Plants are continuously bombarded by an array of potential pathogenic invaders and,
therefore, must enlist an equally diverse set of defense response mechanisms to protect …

Histone deacetylase inhibitors (HDACi) represent a novel class of anticancer compounds
that inhibit tumor cell growth and/or survival by inducing cell cycle arrest at the G1 or G2/M …